94 Results for "

Corydalis ophiocarpa Hook. f. et Thoms.

" in MedChemExpress (MCE) Product Catalog:
Products (94)

94 Results for "Corydalis ophiocarpa Hook. f. et Thoms." in MCE Product Catalog:

6
6 Publications Verification
Referencia número: HY-N0590
No. CAS: 630-94-4
Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
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4
4 Cited Publications
Referencia número: HY-32736
No. CAS: 38647-11-9
Synonyms: NSC 165677; PG 492
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
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4 Cited Publications
Referencia número: HY-N0901
No. CAS: 6877-32-3
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
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2
2 Cited Publications
Referencia número: HY-N0924
No. CAS: 4312-32-7
Synonyms: Tetrahydrocoptisine
(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound. (±)-Stylopine can be isolated from the tubers of the plant Corydalis. (±)-Stylopine inhibits TNF-α, IL-6, and NO production, and attenuates phosphorylation of p38 MAPK, ERK1/2. (±)-Stylopine inhibits NF-κB expression. (±)-Stylopine exhibits anti-inflammatory activity. (±)-Stylopine has protective effects against foot edema, gastric ulcers, anxiety, depression, and acute lung injury .
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2
2 Cited Publications
Referencia número: HY-N0924A
No. CAS: 96087-21-7
Synonyms: Tetrahydrocoptisine hydrochloride
(±)-Stylopine (Tetrahydrocoptisine) hydrochloride is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities .
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1
1 Cited Publications
Referencia número: HY-N0923
No. CAS: 518-69-4
Synonyms: (+)-Corydaline; Corydalin
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .
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1
1 Cited Publications
Referencia número: HY-N2003
No. CAS: 3520-14-7
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .
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1 Cited Publications
Referencia número: HY-N2411
No. CAS: 60314-89-8
Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
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1 Cited Publications
Referencia número: HY-N3035
No. CAS: 38853-67-7
Tetrahydroepiberberine is a isoquinoline alkaloid isolated from Corydalis impatiens (Pall). Tetrahydroepiberberine has antifungal and selective inhibition against the PI-3 virus activities .
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Referencia número: HY-N0654
No. CAS: 27313-86-6
Corypalmine is an alkaloid identified in the dried tubers of Corydalis Decumbens Pers, with an oral bioavailability of 4.6% in mice. Corypalmine exhibits poor gastrointestinal absorption properties, which correlate with its high hydrophilicity and low permeability .
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Referencia número: HY-N0903
No. CAS: 6880-91-7
Synonyms: 12,13-Dihydrochelerythrine
Dihydrochelerythrine is a natural compound isolated from Corydalis yanhusuo; has antifungal activity.
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Referencia número: HY-N5037
No. CAS: 109008-27-7
Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .
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Referencia número: HY-152261
No. CAS: 2891709-58-1
Pureza:  99.2%
Áreas de investigación:  

Cancer

MS6105 is a PROTAC degrader targeting LDHA and LDHB, with DC50 values of 38 nM and 74 nM for degrading LDHA and LDHB in PANC-1 cells, respectively, and no hook effect is observed at high concentrations. MS6105 inhibits the proliferation of pancreatic cancer cells, and no obvious toxicity is observed after intraperitoneal administration in mice. MS6105 can be used for pancreatic cancer-related research .
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Referencia número: HY-N5109
No. CAS: 138664-32-1
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC50s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .
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Referencia número: HY-N0476
No. CAS: 84104-71-2
Synonyms: Regelide; Abruslactone A
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .
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Referencia número: HY-161108
No. CAS: 2597167-34-3
Áreas de investigación:  

Cancer

PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
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Referencia número: HY-101546A
No. CAS: 32728-75-9
Synonyms: (+)-Cavidine
Cavidine ((+)-Cavidine) is an analgesic and anti-inflammatory agent. Cavidine can be isolated from Corydalis ternata f. yanhusuo (Y.H.Chou & Chun C.Hsu) Y.C.Zhu. Cavidine reduces the expression of inflammatory factors IL-1β, IL-6 and TNF-α, and inhibits calcium ion influx. Cavidine inhibits the phosphorylation of p38 and ERK1/2. Cavidine increases mechanical and thermal pain thresholds in chronic pain models. Cavidine can be used for the research of chronic pain .
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Referencia número: HY-N0759
No. CAS: 18797-80-3
Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana, and has anti-inflammatory properties .
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Referencia número: HY-N16525
No. CAS: 2292-20-8
Muramine is an alkaloid. Muramine can be isolated from the bulbs of Corydalis decumbens. Muramine inhibits spontaneous Ca 2+ oscillations. Muramine inhibits neuronal excitability with an IC50 value of 13.5  μM .
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Referencia número: HY-N6894A
No. CAS: 30044-78-1
Synonyms: Isocoptisine chloride
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects .
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